Traumatic Brain Injury (TBI) is now recognized as a causative factor for hormonal deficiencies associated
with personality changes. Psychological, physiological, and physical manifestations like; depression, anxiety, mood swings,
bouts of anger, memory loss, inability to concentrate, learning disabilities, sleep deprivation, increased risk for heart
attacks, strokes, high blood pressure, diabetes, loss of libido, menstrual irregularities, pre-mature menopause, obesity,
loss of lean body mass, muscular weakness, and a number of other medical conditions can arise subsequent to head trauma.
medications (antidepressants, anti-anxiety, anti-seizure, anti-psychotic, and narcotics) do nothing to address the
underlying causes that create the symptoms associated with TBI (Post-Concussion Syndrome) because they do not replenish the
missing hormones. Many individuals under conventional treatment become further dysfunctional from the over-load of medications
used for treating the superficial complaints.
Take some time and review the medical articles that are being published addressing
and acknowledging the association between TBI and Hormonal Dysfunction. Dr. Mark L. Gordon was the first to
provide this relationship on national television after 8 years of sharing the information that already existed. Dr. Gordon
is presently lecturing to other physicians both nationally and internationally on Interventional Endocrinology and
in May 2015, launched a lecture series based upon his recent book entitled:
"TBI - A Clinical Approach
to Diagnosis and Treatment"
8 years of clinical trials based upon hundreds of articles we now have a Perfect Protocol:
The neuro-psychobehavioral characteristics of any one individual
are frequently perceived to be the result of environmental influences. The debate over “nature and nurture” pit our genome against the
influences of our environment in that, we are who we are based upon the company we keep. Or
is it the genes we express? Neuroplasticity under the control of genes and regulated by the hormones that bathe our cerebral
lobes appears to have both genomic and epigenomic influences on how we respond to a variety of environmental challenges; whether-or-not
it is Nurture or Nature. The Neuropsychopharmacology of hormones is an expanding field showing us that the regulation of
reactive emotions from the limbic system is due in part to changes in the gated-ion channels of neurons and their receptors,
thereby influencing our intelligence and emotional presence. It is through the modulation of receptors such as GABAA, GABAB, NMDA, Sigma-1, and AMPA that a group
of hormones produced in the brain and referred to as Neurosteroids influence who and what we are perceived to be and are in
the moment. The
most influential Neurosteroids are those steroids that not only regulate receptors, but also the health and regeneration of
neurons. Representatives of this classification are Progesterone, Allopregnanolone, Estradiol, Testosterone, DiHydroTestosterone,
Pregnenolone and their active sulfated forms all manufactured de novo in the brain.
It is the absolute
or relative loss of these Neurosteroids or a sudden and precipitous change in their relative balances that can lead to alterations
in how we react and how we manage our mental well-being. This is the foundation
of our evaluation and the focus of our treatment protocols.
My position on PTSD
versus TBI is very clear; if there was no physical component to your acute stressor situation that precipitated the condition referred
to as Post-Traumatic Stress Disorder, then it is most likely PTSD. On the other hand, if you had any
physical component, whether it involved the head directly or indirectly, then it is a potential case of Traumatic
Brain Injury. It is my belief, based upon interpretation of 100's of articles suggesting that it is
the interruption of both neurosteroids ( hormones produced in the brain that regulate who we are and how we function)
and neuroactive steroids ( produced in the peripheral glands like testes, ovaries, adrenals and so forth) that cause
the change in our neuro-receptors that regulate mood and intellectual states. It has been my 11 years of experience
in treating mild and moderate TBI cases that the replenishment of neuroactive and neurosteroids to optimal levels has
offered the greatest impact and resolve in each patients' condition. MLG 07-04-2015
Who is at risk of developing psychological
and mood disorders associated with TBI?
returning Veteran; PTSD that has a TBI component, Blast wave
trauma, Repetitive gun fire, Motor Vehicle Accident (MVA), Motorcycle accident, Bicycle accident, Slip and fall, Football related head injuries
( NFL ), Mixed Martial Arts (MMA), Boxing, Work related head injuries (WC), Repetitive
surgeries, Stroke, Cerebral hemorrhage, chemotherapeutic medication, exposure to medical/dental radiation, and just
about any trauma to the body.